ENSP - National School of Public Health, FIOCRUZ, Rio de Janeiro, Brazil
Instituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.
BMJ Open. 2021 Sep 27;11(9):e049011. doi: 10.1136/bmjopen-2021-049011.
Pre-exposure prophylaxis (PrEP) is an important and well-established prevention strategy for sexual acquisition of HIV. In Brazil, transgender women (TGW) and men who have sex with men (MSM) bear the largest burden among key populations. Little is known about preferences for PrEP characteristics in these vulnerable populations in Latin America. The goal of this study is to investigate preferences of TGW and MSM with respect to PrEP characteristics, whether current user or not, and to assess any attributes and levels that may improve the decision to start using PrEP (uptake) and optimal continuity of use (adherence), which are important dimensions for PrEP success.
We hereby outline the protocol of a discrete choice experiment (DCE) to be conducted among TGW and MSM in Brazil. The study will be carried out in two phases. The first phase involves literature review and qualitative approaches including in-depth interviews to inform the development of the DCE (attributes and levels). The second phase entails the DCE survey and supporting questions pertaining to sociodemographic and risk behaviour information. The survey is aimed at current PrEP users and non-users, consisting of two modes of administration: face to face in five Brazilian capitals (Rio de Janeiro, Brasília, Manaus, Porto Alegre and Salvador) and online targeting the entire country. A D-efficient zero-prior blocked experimental design will be used to select 60 paired-profile DCE choice tasks, in which participants will be randomly assigned to one of four groups and presented with a set of 15 choice tasks. The planned sample size is 1000 volunteers.
ETHICS, TIMELINE AND DISSEMINATION: The study was approved by Comitê de Ética em Pesquisa-Instituto Nacional de Infectologia Evandro Chagas-INI/FIOCRUZ, CEP/INI, CAAE 28416220.2.1001.5262, approval number 3.979.759 in accordance with the Comissão Nacional de Ética em Pesquisa (CONEP-Brazilian National Board of Research Ethics). The study will be conducted between 2020 and 2021. The results will be disseminated to the scientific community and to the public in general through publications in published in peer-reviewed journals and in scientific conferences.
暴露前预防（PrEP）是预防性传播艾滋病毒的重要且成熟的策略。在巴西，跨性别女性（TGW）和男男性行为者（MSM）是重点人群中负担最大的人群。在拉丁美洲，关于这些弱势群体对 PrEP 特征的偏好知之甚少。本研究的目的是调查 TGW 和 MSM 是否为当前的 PrEP 用户，调查他们对 PrEP 特征的偏好，以及评估任何可能改善开始使用 PrEP（采用）和最佳持续使用（坚持）决策的属性和水平，这是 PrEP 成功的重要维度。
我们在此概述了一项在巴西 TGW 和 MSM 中进行的离散选择实验（DCE）的方案。该研究将分两个阶段进行。第一阶段包括文献回顾和定性方法，包括深入访谈，为 DCE（属性和水平）的制定提供信息。第二阶段涉及 DCE 调查以及与社会人口学和风险行为信息相关的支持性问题。该调查针对当前的 PrEP 用户和非用户，包括两种管理模式：在巴西五个首府（里约热内卢、巴西利亚、马瑙斯、阿雷格里港和萨尔瓦多）进行面对面调查和针对全国的在线调查。将使用 D-有效零先验块实验设计来选择 60 对配对简档 DCE 选择任务，参与者将被随机分配到四个组之一，并呈现一组 15 个选择任务。计划的样本量为 1000 名志愿者。
伦理、时间表和传播：该研究已获得 Comitê de Ética em Pesquisa-Instituto Nacional de Infectologia Evandro Chagas-INI/FIOCRUZ，CEP/INI，CAAE 28416220.2.1001.5262 的批准，编号为 3.979.759，符合 Comissão Nacional de Ética em Pesquisa（巴西国家研究伦理委员会）的规定。该研究将于 2020 年至 2021 年进行。研究结果将通过发表在同行评议期刊和科学会议上的出版物向科学界和公众传播。
