Basso D, Fabris C, Del Favero G, Panucci A, Piccoli A, Plebani M, Pedrazzoli S, Baccaglini U, Lise M, Burlina A
Minerva Med. 1986 Apr 14;77(16):613-6.
In order to assess the relative value of CA 19-9, Tissue Polypeptide Antigen (TPA) and Carcinoembryonic Antigen (CEA), evaluated alone and in combination, in diagnosing pancreatic malignancy, serum CA 19-9, TPA and CEA were determined in 25 control subjects (CS), 26 pancreatic cancer (PC), 23 chronic pancreatitis (CP) and 21 benign extra-pancreatic diseases (EPD). The three markers were able to allocate the subjects correctly in 56.8% of the cases (CS 100%, PC 73.1%, CP 17.4%, EPD 28.6%). Sensitivity, specificity and diagnostic accuracy in detecting pancreatic cancer were respectively: 77%, 91% and 68% for CA 19-9; 92%, 75% and 67% for TPA; 50%, 84% and 34% for CEA; 73%, 91% and 64% for the three parameters evaluated simultaneously. CA 19-9 and TPA appear to be useful indices of pancreatic cancer with a satisfactory specificity when related to chronic pancreatitis; their diagnostic value seems to be comparable and better than that of CEA; the combination of these markers does not improve the results obtained by CA 19-9 or TPA alone.
为了评估单独及联合检测糖类抗原19-9（CA 19-9）、组织多肽抗原（TPA）和癌胚抗原（CEA）在诊断胰腺恶性肿瘤中的相对价值，我们测定了25名对照者（CS）、26例胰腺癌（PC）患者、23例慢性胰腺炎（CP）患者及21例胰腺外良性疾病（EPD）患者的血清CA 19-9、TPA和CEA。这三种标志物在56.8%的病例中能够正确区分受试者（CS 100%，PC 73.1%，CP 17.4%，EPD 28.6%）。检测胰腺癌时，CA 19-9的敏感性、特异性和诊断准确性分别为77%、91%和68%；TPA分别为92%、75%和67%；CEA分别为50%、84%和34%；同时检测这三个参数时分别为73%、91%和64%。CA 19-9和TPA似乎是胰腺癌的有用指标，与慢性胰腺炎相比具有令人满意的特异性；它们的诊断价值似乎相当且优于CEA；这些标志物的联合检测并未改善单独使用CA 19-9或TPA所获得的结果。
