Pasanen P A, Eskelinen M, Partanen K, Pikkarainen P, Penttila I
Department of Surgery, Kuopio University Hospital, Finland.
Anticancer Res. 1993 Sep-Oct;13(5C):1883-7.
The serum values of tissue polypeptide antigen (TPA) were measured in a prospective series of 100 patients with jaundice, 54 patients with suspicion of chronic pancreatitis or a pancreatic tumour, and 19 patients with unjaundiced cholestasis to assess its value in diagnosing pancreatic cancer. There were altogether 25 patients with a cancer of the pancreas including 2 patients with a cancer of the papilla of Vater. The highest serum TPA values were noticed in patients with pancreatic cancer, but raised values were also seen in patients with malignant or benign liver diseases, and with cholangiocarcinoma. The sensitivity of TPA was 52% with a specificity of 85% and an efficiency of 80%. In comparison to CEA, CA 50 and CA 242, TPA showed lower sensitivity but higher specificity. When TPA was combined with the other markers, the specificity and efficiency improved clearly in all combinations, being highest in that of TPA and CA 242 (specificity 94.5%, efficiency 87.2%). The results suggest that the TPA test has a useful complementary role in the clinical use of the current serum tumour markers in the diagnosis of pancreatic cancer.
对100例黄疸患者、54例疑似慢性胰腺炎或胰腺肿瘤患者以及19例无黄疸性胆汁淤积患者进行了前瞻性研究，检测其组织多肽抗原（TPA）的血清值，以评估其在胰腺癌诊断中的价值。共有25例胰腺癌患者，其中包括2例 Vater 乳头癌患者。胰腺癌患者的血清TPA值最高，但在恶性或良性肝病以及胆管癌患者中也可见升高。TPA的敏感性为52%，特异性为85%，效率为80%。与癌胚抗原（CEA）、CA 50和CA 242相比，TPA的敏感性较低，但特异性较高。当TPA与其他标志物联合使用时，所有组合的特异性和效率均明显提高，其中TPA与CA 242联合时最高（特异性94.5%，效率87.2%）。结果表明，TPA检测在目前血清肿瘤标志物诊断胰腺癌的临床应用中具有有益的补充作用。
