Department of Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.
USAID Advancing Nutrition, Arlington, Virginia.
Ann N Y Acad Sci. 2022 Feb;1508(1):105-122. doi: 10.1111/nyas.14697. Epub 2021 Sep 28.
Large-scale food fortification may be a cost-effective intervention to increase micronutrient supplies in the food system when implemented under appropriate conditions, yet it is unclear if current strategies can equitably benefit populations with the greatest micronutrient needs. This study developed a mathematical modeling framework for comparing fortification scenarios across different contexts. It was applied to model the potential contributions of three fortification vehicles (oil, sugar, and wheat flour) toward meeting dietary micronutrient requirements in Malawi through secondary data analyses of a Household Consumption and Expenditure Survey. We estimated fortification vehicle coverage, micronutrient density of the diet, and apparent intake of nonpregnant, nonlactating women for nine different micronutrients, under three food fortification scenarios and stratified by subpopulations across seasons. Oil and sugar had high coverage and apparent consumption that, when combined, were predicted to improve the vitamin A adequacy of the diet. Wheat flour contributed little to estimated dietary micronutrient supplies due to low apparent consumption. Potential contributions of all fortification vehicles were low in rural populations of the lowest socioeconomic position. While the model predicted large-scale food fortification would contribute to reducing vitamin A inadequacies, other interventions are necessary to meet other micronutrient requirements, especially for the rural poor.
大规模食品强化可能是增加食物系统微量营养素供应的一种具有成本效益的干预措施,但目前的策略是否能公平惠及对微量营养素需求最大的人群还不清楚。本研究开发了一个数学建模框架,用于比较不同背景下的强化方案。它应用于通过对家庭消费和支出调查的二次数据分析,为在马拉维通过三种强化载体(油、糖和小麦粉)来满足膳食微量营养素需求的情况建模。我们根据不同季节的子群体,在三种食物强化方案下,估计了强化载体的覆盖率、饮食中的微量营养素密度和非妊娠、非哺乳期妇女的表观摄入量,针对九种不同的微量营养素。油和糖的覆盖率和表观摄入量都很高,两者结合预计能改善饮食中维生素 A 的充足性。由于表观摄入量低,小麦粉对估计的膳食微量营养素供应的贡献很小。社会经济地位最低的农村人口中,所有强化载体的潜在贡献都很低。虽然该模型预测大规模食品强化将有助于减少维生素 A 不足,但还需要其他干预措施来满足其他微量营养素的需求,尤其是针对农村贫困人口。