[大戟树脂大戟三萜类化合物的化学成分]

[Chemical constituents of triterpenoids from Euphorbia resinifera].

作者信息

Li Ya-Jie, Ji Teng-Fei, Zhao Jun, Gu Zheng-Yi

机构信息

College of Pharmacy, Xinjiang Medical University Urumqi 830011, China.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &Peking Union Medical College Beijing 100050, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(17):4433-4437. doi: 10.19540/j.cnki.cjcmm.20210621.201.

DOI:10.19540/j.cnki.cjcmm.20210621.201

PMID:34581047

Abstract

The combination of normal-phase silica gel column chromatography, octadecyl silica(ODS) column chromatography, semi-preparative high performance liquid chromatography(HPLC), etc. was employed to isolate and purify the chemical components from Euphorbia resinifera, and 7 triterpenoids were separated from the ethanol extract of the medicinal materials. Their structures were identified by various spectroscopy methods as cycloartan-1,24-diene-3-one(1), cycloartan-1,24-diene-3-ol(2), 3β-hydroxy-lanosta-8,24-diene-11-one(3), lnonotusane C(4), eupha-8,24-diene-3β-ol-7,11-dione(5), eupha-24-methylene-8-ene-3β-ol-7,11-dione(6), and eupha-8,24-diene-3β,11β-diol-7-one(7). Compounds 1 and 2 are new compounds, and compound 3 is obtained from nature for the first time.

摘要

采用正相硅胶柱色谱、十八烷基硅胶（ODS）柱色谱、半制备高效液相色谱（HPLC）等方法从树脂大戟中分离纯化化学成分，从该药材的乙醇提取物中分离得到7个三萜类化合物。通过各种光谱方法鉴定其结构为环阿尔廷-1,24-二烯-3-酮（1）、环阿尔廷-1,24-二烯-3-醇（2）、3β-羟基-羊毛甾-8,24-二烯-11-酮（3）、诺努托烷C（4）、大戟-8,24-二烯-3β-醇-7,11-二酮（5）、大戟-24-亚甲基-8-烯-3β-醇-7,11-二酮（6）和大戟-8,24-二烯-3β,11β-二醇-7-酮（7）。化合物1和2为新化合物，化合物3为首次从自然界获得。