[大戟树脂大戟乳汁中的四种新羊毛甾烷三萜类化合物]
[Four new lanostane triterpenoids from latex of Euphorbia resinifera].
作者信息
Li Miao-Miao, Qi Yan-Ru, Feng Ya-Ping, Liu Wei, Yuan Tao
机构信息
College of Life Science, Jiangxi Normal University Nanchang 330022, China.
College of Life Science, Jiangxi Normal University Nanchang 330022, China Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, Yili Normal University Yining 835000, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4744-4748. doi: 10.19540/j.cnki.cjcmm.20210623.201.
Four new lanostane triterpenoids, 3β-hydroxy-12α-methoxylanosta-7,9(11),24-triene(1), 3β-hydroxy-12α-methoxy-24-methylene-lanost-7,9(11)-dien(2), 3,7-dioxo-lanosta-8,24-diene(3), and 3,7-dioxo-24-methylene-lanost-8-en(4), were isolated from the latex of Euphorbia resinifera with a variety of chromatography methods. Their structures were elucidated based on spectroscopic data and/or comparison with the data reported in previous research. Compounds 1, 2, and 4 showed moderate inhibition of LPS-induced NO production by RAW264.7, with IC_(50) of 30.4, 37.5, and 28.3 μmol·L~(-1), respectively.
采用多种色谱方法从树脂大戟的乳胶中分离出4种新的羊毛甾烷型三萜类化合物，分别为3β-羟基-12α-甲氧基羊毛甾-7,9(11),24-三烯(1)、3β-羟基-12α-甲氧基-24-亚甲基羊毛甾-7,9(11)-二烯(2)、3,7-二氧代羊毛甾-8,24-二烯(3)和3,7-二氧代-24-亚甲基羊毛甾-8-烯(4)。基于光谱数据和/或与先前研究报道的数据进行比较，阐明了它们的结构。化合物1、2和4对RAW264.7细胞中脂多糖诱导的NO生成具有中等程度的抑制作用，IC50分别为30.4、37.5和28.3 μmol·L-1。
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