Ma Zi-Hao, Ma Jie, Lyu Jin-Ying, He Juan, Jia Duo-Wu-Ni, Yang Xiao, Qu Yan, Zeng Rui
School of Pharmacy, Southwest Minzu University Chengdu 610041, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4666-4673. doi: 10.19540/j.cnki.cjcmm.20210528.604.
As the main active ingredient of the orchidaceous herb Bletilla striata, B. striata polysaccharide(BSP) has pharmacological activities such as promoting coagulation, anti-inflammation, anti-oxidation, promoting wound healing, anti-tumor, and immunomodulation, and is biodegradable and non-toxic. Additionally, it has the material properties of suspension thickening, film-forming adhesion, coating and solubilizing, targeting and slow releasing, effect-enhancing and toxicity-reducing, etc., playing the role of unification of medicines and excipients. Therefore, BSP has a wide application prospect in the fields of drug delivery system and trauma repair. This paper reviews the research progress of BSP application in new drug delivery systems and biomaterials based on the related li-terature in recent years, with the aim of providing reference for the further research and application of BSP.
作为兰科植物白及的主要活性成分，白及多糖（BSP）具有促进凝血、抗炎、抗氧化、促进伤口愈合、抗肿瘤和免疫调节等药理活性，且具有生物可降解性和无毒的特点。此外，它还具有悬浮增稠、成膜黏附、包衣和增溶、靶向缓释、增效减毒等材料特性，发挥着药物与辅料统一的作用。因此，BSP在药物递送系统和创伤修复领域具有广阔的应用前景。本文基于近年来的相关文献，综述了BSP在新型药物递送系统和生物材料中的应用研究进展，旨在为BSP的进一步研究和应用提供参考。
