Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China; The State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Int J Biol Macromol. 2024 Jan;254(Pt 1):127643. doi: 10.1016/j.ijbiomac.2023.127643. Epub 2023 Oct 26.
Bletilla striata has been used for thousands of years and shows the functions of stopping bleeding, reducing swelling, and promoting healing in traditional applications. For Bletilla striata, Bletilla striata polysaccharides (BSP) is the main active ingredient, exhibiting biological functions of anti-inflammatory, anti-oxidant, anti-fibrotic, immune modulation, anti-glycation, and so on. In addition, BSP has exhibited the characteristics of excipient such as bio-adhesion, bio-degradability, and bio-safety and has been prepared into a series of preparations such as nanoparticles, microspheres, microneedles, hydrogels, etc. BSP, as both a drug and an excipient, has already aroused more and more attention. In this review, publications in recent years related to the extraction and identification, biological activities, and excipient application of BSP are reviewed. Specifically, we focused on the advances in the application of BSP as a formulation excipient. We hold opinion that BSP not only needed more researches in the mechanisms, but also the development into hydrogels, nano-formulations, tissue engineering, and so on. And we believe that this paper provides a beneficial reference for further BSP innovation and in-depth research and promotes the use of these natural products in pharmaceutical applications.
白及已被应用数千年，在传统应用中具有止血、消肿和促进愈合的功能。对于白及来说，白及多糖（BSP）是主要的活性成分，具有抗炎、抗氧化、抗纤维化、免疫调节、抗糖化等生物学功能。此外，BSP 还表现出辅料的特性，如生物黏附性、生物降解性和生物安全性，并已被制备成纳米粒、微球、微针、水凝胶等一系列制剂。BSP 作为药物和辅料，已经引起了越来越多的关注。本综述对近年来有关 BSP 的提取与鉴定、生物活性和辅料应用的文献进行了回顾。具体来说，我们重点介绍了 BSP 作为制剂辅料的应用进展。我们认为 BSP 不仅需要在机制方面进行更多的研究，还需要将其开发成水凝胶、纳米制剂、组织工程等。我们相信，本文为进一步的 BSP 创新和深入研究提供了有益的参考，并促进了这些天然产物在药物应用中的使用。
