Airoldi M, Piantino P, Pacchioni D, Mastromatteo V, Pedani F, Gandolfo S
Oral Surg Oral Med Oral Pathol. 1986 Mar;61(3):263-7. doi: 10.1016/0030-4220(86)90372-5.
Gastrointestinal cancer-associated antigen (GICA) is detected by means of a monoclonal antibody in the serum and pathologic tissues of patients with gastrointestinal tumors. This article compares serum and salivary GICA and carcinoembryonic antigen (CEA) levels in 19 healthy control subjects, 17 patients with benign oral cavity lesions, and 11 patients with squamous cell carcinoma of the oral cavity. Serum CEA levels were similar in all three groups, whereas salivary CEA levels were higher in patients with squamous cell carcinoma than in the control subjects (p less than 0.001) and the patients with benign lesions (p less than 0.025). Serum GICA levels gave the opposite result and were significantly lower in squamous cell cancer when compared with control subjects (p less than 0.0001) and patients with benign lesions (p less than 0.02). Values of GICA in saliva of patients with oral cancer were also lower than in the control subjects (p less than 0.02). The possible significance of this difference between the two antigens is discussed.
采用单克隆抗体检测胃肠道肿瘤患者血清及病理组织中的胃肠癌相关抗原（GICA）。本文比较了19名健康对照者、17例口腔良性病变患者和11例口腔鳞状细胞癌患者血清及唾液中的GICA和癌胚抗原（CEA）水平。三组患者的血清CEA水平相似，而口腔鳞状细胞癌患者的唾液CEA水平高于对照者（p<0.001）和良性病变患者（p<0.025）。血清GICA水平结果相反，与对照者（p<0.0001）和良性病变患者相比，鳞状细胞癌患者的血清GICA水平显著降低（p<0.02）。口腔癌患者唾液中的GICA值也低于对照者（p<0.02）。文中讨论了这两种抗原之间差异的可能意义。
