Negri L, Pacchioni D, Calabrese F, Giacomasso S, Mastromatteo V, Fazio M
Faculty of Medical Oncology, University of Turin, Italy.
Int J Biol Markers. 1988 Apr-Jun;3(2):107-12.
The gastrointestinal cancer-associated antigen (GICA) is recognised by a monoclonal antibody in both serum and tissues of patients with neoplasm of the GI tract. This study compared the serum and saliva values of carcinoembryonic antigen (CEA) and GICA in 19 healthy subjects, 43 patients with benign oral cavity lesions and 26 with histologically confirmed squamous-cell carcinomas. Serum CEA levels were much the same in all three groups, whereas salivary values were significantly higher (p less than 0.001) in both patient groups than in the controls. Serum GICA gave the opposite result: lower in carcinoma than in controls (p less than 0.001) and benign lesions (N.S.), while salivary GICA was significantly lower in carcinoma than in both the other two groups (p less than 0.001). The meaning of this difference between the values for the two antigens is discussed.
胃肠道癌相关抗原（GICA）在胃肠道肿瘤患者的血清和组织中均可被一种单克隆抗体识别。本研究比较了19名健康受试者、43例口腔良性病变患者和26例经组织学确诊的鳞状细胞癌患者血清和唾液中癌胚抗原（CEA）及GICA的水平。三组患者的血清CEA水平大致相同，而两个患者组的唾液CEA水平均显著高于对照组（p<0.001）。血清GICA的结果则相反：癌症患者血清GICA水平低于对照组（p<0.001）和良性病变组（无显著性差异），而癌症患者唾液GICA水平显著低于另外两组（p<0.001）。本文讨论了这两种抗原水平差异的意义。
