Boyce B F, Prime S S, Halls D, Johnston E, Critchlow H, MacDonald D G, Junor B J
Oral Surg Oral Med Oral Pathol. 1986 Mar;61(3):272-7. doi: 10.1016/0030-4220(86)90374-9.
Two renal dialysis patients with oral manifestations of oxalosis had undecalcified sections of iliac and alveolar bone and teeth examined histologically in an attempt to explain the development of tooth mobility and tooth loss. Osteomalacia was detected in all bone specimens and attributed to aluminum toxicity after the histochemical localization of aluminum at the calcification front between osteoid and calcified matrix. Aluminum was also detected histochemically in the cementum of teeth. Calcium oxalate crystals were present in bone marrow, teeth, and gingiva. It is proposed that tooth mobility and tooth loss in oxalosis result from the combined effects of osteomalacia and oxalate crystal deposition within the periodontium. To prevent avoidable tooth loss it is suggested that patients with oxalosis who develop tooth mobility should have aluminum toxicity and osteomalacia excluded as causal factors.
两名患有草酸中毒口腔表现的肾透析患者接受了髂骨、牙槽骨和牙齿的未脱钙切片组织学检查，以试图解释牙齿松动和牙齿脱落的发生机制。在所有骨标本中均检测到骨软化症，在类骨质与钙化基质之间的钙化前沿进行铝的组织化学定位后，将其归因于铝中毒。在牙齿的牙骨质中也通过组织化学检测到了铝。草酸钙晶体存在于骨髓、牙齿和牙龈中。有人提出，草酸中毒时牙齿松动和牙齿脱落是由骨软化症和草酸钙晶体在牙周组织内沉积的联合作用导致的。为防止可避免的牙齿脱落，建议出现牙齿松动的草酸中毒患者排除铝中毒和骨软化症作为致病因素。
