Department of Microbiology and Cell Biology, Cardiovascular and Muscle Research Laboratory, Indian Institute of Science, Bengaluru, India.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
FASEB J. 2021 Oct;35(10):e21841. doi: 10.1096/fj.202100490R.
Sirtuins are a family of NAD -dependent deacetylases implicated in a wide variety of age-associated pathologies, including cardiovascular disorders. Among the seven mammalian sirtuins, SIRT2 modulates various cellular processes through the deacetylation or deacylation of their target proteins. Notably, the levels of SIRT2 in the heart decline with age and other pathological conditions, leading to cardiovascular dysfunction. In the present review, we discuss the emerging roles of SIRT2 in cardiovascular dysfunction and heart failure associated with factors like age, hypertension, oxidative stress, and diabetes. We also discuss the potential of using inhibitors to study the unexplored role of SIRT2 in the heart. While SIRT2 undoubtedly plays a crucial role in the cardiovascular system, its functions are only beginning to be understood, making it an attractive candidate for further research in the field.
Sirtuins 是一组依赖 NAD 的去乙酰化酶，与多种与年龄相关的病理学有关，包括心血管疾病。在七种哺乳动物的 Sirtuins 中，SIRT2 通过去乙酰化或去酰化其靶蛋白来调节各种细胞过程。值得注意的是，SIRT2 在心脏中的水平随着年龄的增长和其他病理状况而下降，导致心血管功能障碍。在本综述中，我们讨论了 SIRT2 在与年龄、高血压、氧化应激和糖尿病等因素相关的心血管功能障碍和心力衰竭中的作用。我们还讨论了使用抑制剂来研究 SIRT2 在心脏中未被探索的作用的潜力。虽然 SIRT2 无疑在心血管系统中起着至关重要的作用，但它的功能才刚刚开始被理解，这使其成为该领域进一步研究的有吸引力的候选者。
