Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland.
Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
Int J Mol Sci. 2023 Jan 12;24(2):1532. doi: 10.3390/ijms24021532.
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease leading to joint destruction. The causes of RA are not fully known. Most likely, the development of the disease depends on the coexistence of many factors, such as hereditary factors, immune system defects, gender, infectious agents, nicotine, and stress. Various epigenetic changes have been identified and correlated with the aggressive phenotype of RA, including the involvement of sirtuins, which are enzymes found in all living organisms. Their high content in the human body can slow down the aging processes, reduce cell death, counteract the appearance of inflammation, and regulate metabolic processes. Sirtuins can participate in several steps of RA pathogenesis. This narrative review presents, collects, and discusses the role of all sirtuins (1-7) in the pathogenesis of rheumatoid arthritis.
类风湿关节炎（RA）是一种自身免疫性和炎症性疾病，可导致关节破坏。RA 的病因尚未完全明确。很可能，疾病的发展取决于许多因素的共存，如遗传因素、免疫系统缺陷、性别、病原体、尼古丁和压力。已经确定了各种表观遗传变化，并与 RA 的侵袭性表型相关，包括参与所有生物体中发现的酶——沉默调节蛋白（sirtuins）的作用。其在人体内的高含量可以减缓衰老过程，减少细胞死亡，对抗炎症的出现，并调节代谢过程。沉默调节蛋白可以参与 RA 发病机制的几个步骤。本综述介绍、收集并讨论了所有沉默调节蛋白（1-7）在类风湿关节炎发病机制中的作用。
