Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Dev Cell. 2021 Sep 27;56(18):2545-2546. doi: 10.1016/j.devcel.2021.09.003.
Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.
在培养细胞中耗尽 CTCF 对转录的影响较小，而其突变则导致胚胎致死和发育缺陷。在最近一期的《自然细胞生物学》杂志上，Soochit 等人（2021）表明 CTCF 在 DNA 上的停留时间可能解释了其在细胞分化中的关键作用。
