Harley J B, Reichlin M, Arnett F C, Alexander E L, Bias W B, Provost T T
Science. 1986 May 30;232(4754):1145-7. doi: 10.1126/science.3458307.
Primary Sjögren's syndrome is an autoimmune disorder characterized by dryness of the mouth and eyes. The human leukocyte antigen (HLA) locus DQ is related to the primary Sjögren's syndrome autoantibodies that bind the RNA proteins Ro/SSA and La/SSB. Both DQ1 and DQ2 alleles are associated with high concentrations of these autoantibodies. An analysis of all possible combinations at DQ has shown that the entire effect was due to heterozygotes expressing the DQ1 and DQ2 alleles. These data suggest that gene interaction between DQ1 and DQ2 (or alleles at associated loci), possibly from gene complementation of trans-associated surface molecules, influences the autoimmune response in primary Sjögren's syndrome.
原发性干燥综合征是一种以口干和眼干为特征的自身免疫性疾病。人类白细胞抗原（HLA）基因座DQ与结合RNA蛋白Ro/SSA和La/SSB的原发性干燥综合征自身抗体相关。DQ1和DQ2等位基因均与这些自身抗体的高浓度有关。对DQ所有可能组合的分析表明，整体效应归因于表达DQ1和DQ2等位基因的杂合子。这些数据表明，DQ1和DQ2（或相关基因座的等位基因）之间的基因相互作用，可能来自反式相关表面分子的基因互补，影响原发性干燥综合征的自身免疫反应。
