Centre for Adolescent Health (Kinner), Murdoch Children's Research Institute; Melbourne School of Population and Global Health (Kinner), University of Melbourne, Parkville, Victoria, Australia; British Columbia Centre for Disease Control (Gan, Slaunwhite); School of Population and Public Health (Slaunwhite), University of British Columbia, Vancouver, BC
Centre for Adolescent Health (Kinner), Murdoch Children's Research Institute; Melbourne School of Population and Global Health (Kinner), University of Melbourne, Parkville, Victoria, Australia; British Columbia Centre for Disease Control (Gan, Slaunwhite); School of Population and Public Health (Slaunwhite), University of British Columbia, Vancouver, BC.
CMAJ Open. 2021 Sep 28;9(3):E907-E914. doi: 10.9778/cmajo.20200243. Print 2021 Jul-Sep.
People recently released from prison are at increased risk of preventable death; however, the impact of the current overdose epidemic on this population is unknown. We aimed to document the incidence and identify risk factors for fatal overdose after release from provincial prisons in British Columbia.
We conducted a retrospective, population-based, open cohort study of adults released from prisons in BC, using linked administrative data. Within a random 20% sample of the BC population, we linked provincial health and correctional records from 2010 to 2017 for people aged 23 years or older as of Jan. 1, 2015, who were released from provincial prisons at least once from 2015 to 2017. We identified exposures that occurred from 2010 to 2017 and deaths from 2015 to 2017. We calculated the piecewise incidence of overdose-related and all-cause deaths after release from prison. We used multivariable, mixed-effects Cox regression to identify predictors of all-cause death and death from overdose.
Among 6106 adults released from prison from 2015 to 2017 and followed in the community for a median of 1.6 (interquartile range 0.9-2.3) years, 154 (2.5%) died, 108 (1.8%) from overdose. The incidence of all-cause death was 16.1 (95% confidence interval [CI] 13.7-18.8) per 1000 person-years. The incidence of overdose deaths was 11.2 (95% CI 9.2-13.5) per 1000 person-years, but 38.8 (95% CI 3.2-22.6) in the first 2 weeks after release from prison. After adjustment for covariates, the hazard of overdose death was 4 times higher among those who had been dispensed opioids for pain.
People released from prisons in BC are at markedly increased risk of overdose death. Overdose prevention must go beyond provision of opioid agonist treatment and naloxone on release to address systemic social and health inequities that increase the risk of premature death.
刚出狱的人面临更高的可预防死亡风险;然而,当前的过量用药流行对这一人群的影响尚不清楚。我们旨在记录不列颠哥伦比亚省监狱释放后致命过量用药的发生率并确定其危险因素。
我们开展了一项回顾性、基于人群的开放队列研究,对不列颠哥伦比亚省监狱释放的成年人进行研究,使用了关联的行政数据。在不列颠哥伦比亚省人群中随机抽取 20%的样本,我们将 2010 年至 2017 年的省级健康和惩教记录与截至 2015 年 1 月 1 日年龄在 23 岁或以上的人进行了关联,这些人在 2015 年至 2017 年期间至少有一次从监狱释放。我们确定了 2010 年至 2017 年期间的暴露情况和 2015 年至 2017 年期间的死亡情况。我们计算了从监狱释放后的与过量用药相关的和所有原因的死亡的分段发生率。我们使用多变量、混合效应 Cox 回归来确定全因死亡和过量用药死亡的预测因素。
在 2015 年至 2017 年期间从监狱释放并在社区中随访中位数为 1.6 年(四分位间距 0.9-2.3 年)的 6106 名成年人中,有 154 人(2.5%)死亡,108 人(1.8%)死于过量用药。全因死亡的发生率为每 1000 人年 16.1(95%置信区间[CI]13.7-18.8)。过量用药死亡的发生率为每 1000 人年 11.2(95%CI9.2-13.5),但在从监狱释放后的前 2 周内发生率为 38.8(95%CI3.2-22.6)。调整协变量后,因疼痛而被配给阿片类药物的人过量用药死亡的风险是其他人的 4 倍。
从不列颠哥伦比亚省监狱释放的人过量用药死亡的风险显著增加。在释放时,除了提供阿片类药物激动剂治疗和纳洛酮外,还必须采取预防过量用药的措施,以解决增加过早死亡风险的系统性社会和健康不平等问题。