Department of Radiation Physics, Unit 1420, The University of Texas MD Anderson Cancer Center, 1400 Pressler St., Houston, TX, USA.
Convergent R.N.R, 2 Yozma St., 3903202, Tirat Carmel, Israel.
Sci Rep. 2021 Sep 28;11(1):19180. doi: 10.1038/s41598-021-98888-8.
We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy.
我们描述了一种新的远距治疗模式的发展和分析,该模式通过一种新颖的靶向放射治疗方法,有可能比传统的基于光子的治疗提供更大的适形性。所提出的系统使用 X 射线透镜将来自常规 X 射线管的光子反射到焦点。得到的剂量分布具有非常局域的高峰剂量,在收敛辐射锥中有较低的剂量。提出了用于设计该系统的物理原理,并进行了一系列测量,分析了收敛光束的各种特性。该光束被设计为几乎单能(约 59keV),能量带宽约为 10keV,允许使用低于常规治疗的治疗能量。焦点的测量结果约为 2.5cm 长,4mm 宽。将所提出的 X 射线输送系统安装在机械臂上,可以实现焦点位置的亚毫米精度,通过在靶体积内最佳放置单个焦点来实现高度适形的剂量分布。考虑到收敛 X 射线束治疗所提供的独特特性,我们讨论了这种新型辐射束的各个方面,作为一种治疗方法,可以最大限度地利用这些特性。