Soedjana H, Lukman K, Harianti S
Faculty of Medicine Universitas Padjajaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Ann Burns Fire Disasters. 2021 Jun 30;34(2):157-162.
Burn injury is still a global health problem due to its high incidence. Healing of burn wounds requires an optimal state of the body that is characterized by serum albumin level, especially in the category of patients that require skin graft to cover the wound caused by the deep burn. This study investigates the relationship between albumin levels and the outcome of split-thickness skin graft (STSG) and obtains a tolerance limit for albumin levels that can be successful in STSG. This was a prospective cohort study at our Plastic Surgery Center in Bandung, West Java, Indonesia from June 2019 to November 2020. Fortyseven burn injury patients who had undergone STSG qualified as the study subjects based on the criteria set. Of these patients, 85.11% were male and 68.08% were in the productive age. Preoperative albumin level has no significant correlation with graft outcome (P>0.05). Area Under the Curve (AUC) is 0.758; (95% CI: 0.605, 0.910). The optimal cut-off point for albumin levels is 2.175 (sensitivity of 0.78 and a specificity of 0.714). In our study, graft healing has no significant correlation with albumin levels. Further study is needed to assess the relationship between serum albumin levels (preoperative and postoperative) with outcome of the graft, and assess infection status.
由于烧伤发生率高，烧伤仍是一个全球性的健康问题。烧伤创面的愈合需要身体处于最佳状态，这以血清白蛋白水平为特征，特别是在需要皮肤移植来覆盖深度烧伤所致创面的患者类别中。本研究调查白蛋白水平与中厚皮片移植（STSG）结果之间的关系，并获得在STSG中可能成功的白蛋白水平耐受限度。这是一项于2019年6月至2020年11月在印度尼西亚西爪哇万隆我们的整形外科中心进行的前瞻性队列研究。根据设定的标准，47例接受了STSG的烧伤患者符合作为研究对象的条件。在这些患者中，85.11%为男性，68.08%处于生产年龄。术前白蛋白水平与移植结果无显著相关性（P>0.05）。曲线下面积（AUC）为0.758；（95%CI：0.605，0.910）。白蛋白水平的最佳截断点为2.175（敏感性为0.78，特异性为0.714）。在我们的研究中，移植愈合与白蛋白水平无显著相关性。需要进一步研究以评估血清白蛋白水平（术前和术后）与移植结果之间的关系，并评估感染状况。
