Terkawi Rayan S, Qutob Dua', Hendaus Mohamed A
Division of General Pediatrics, Department of Pediatrics Sidra Medicine Ar-Rayyan Qatar.
Division of General Pediatrics, Department of Pediatrics Hamad Medical Corporation Doha Qatar.
JGH Open. 2021 Aug 7;5(9):988-996. doi: 10.1002/jgh3.12621. eCollection 2021 Sep.
Multiseptated gallbladder (MSG) (also known as "Honeycomb gallbladder") is a rare condition that was first described by Knetsch in 1952, and there are around 150 cases described over the world. MSG has been described as a congenital anomaly in most of the cases and as acquired in a few. Moreover, the phenomenon was described with a variety of different symptoms and management. The aim of this article is to have better understanding of this condition and management approach. We are reporting a 4-year-old girl, who presented to Sidra Medicine, Qatar with MSG. We have also included 97 cases for review and analysis. The median age of presentation of the condition was 27 years but may present in neonates and in the elderly, while gender was not a risk factor. Abdominal pain is the most common presenting symptom, but it can present without symptoms. Certain congenital anomalies were detected in the pancreaticobiliary system in few patients with MSG. Medical treatment was reported in eight symptomatic patients, four of whom failed therapy. Cholecystectomy was performed in 40 patients, which resulted in resolutions of symptoms in 13 of them. Based on the available literature, congenital MSG is probably due to in-pouching of gallbladder wall to its own cavity forming septa containing muscular fibers. MSG can be diagnosed solely via imaging, and ultrasound appears to be an effective and feasible mode of diagnosis. Medical treatment efficacy is not well-known, but cholecystectomy has resulted in complete resolution in symptomatic patients.
多分隔胆囊（MSG）（也称为“蜂窝状胆囊”）是一种罕见病症，1952年由克内奇首次描述，全世界报道的病例约有150例。大多数病例中，MSG被描述为先天性异常，少数为后天性。此外，该现象伴有多种不同症状和处理方式。本文旨在更好地了解这种病症及其处理方法。我们报告了一名4岁女孩，她因多分隔胆囊就诊于卡塔尔的西德拉医学中心。我们还纳入了97例病例进行回顾和分析。该病症的中位发病年龄为27岁，但新生儿和老年人也可能发病，性别不是危险因素。腹痛是最常见的症状表现，但也可能无症状。少数多分隔胆囊患者的胰胆管系统检测到某些先天性异常。8例有症状患者接受了药物治疗，其中4例治疗失败。40例患者接受了胆囊切除术，其中13例症状得到缓解。根据现有文献，先天性多分隔胆囊可能是由于胆囊壁向自身腔内凹陷形成含有肌纤维的间隔。多分隔胆囊仅通过影像学检查即可诊断，超声似乎是一种有效且可行的诊断方式。药物治疗效果尚不清楚，但胆囊切除术已使有症状患者完全康复。
