Department of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus/Shanghai Fengxian District Central Hospital, Shanghai 201499, China.
Department of Orthopedics, Shanghai Sixth People's Hospital, China.
Biomater Sci. 2021 Oct 26;9(21):7228-7236. doi: 10.1039/d1bm00175b.
Photodynamic and ferroptosis therapies for cancer treatment are restricted by the scarcity of oxygen and Fe in cancer cells, and the complicated structure of delivery systems. Herein, a red blood cell-derived vehicle (RDV) inherently enriched with hemoglobin co-delivers a photosensitizer, Ce6, and a ferroptosis promoter, sorafenib (SRF) into cancer cells for boosting oxygen and providing iron, which leads to enhanced PDT and stronger ferroptosis therapy. Damage to the RDV membrane under local irradation leads to SRF release at the tumor site for tumor-targeted therapy. The lipid membrane of the RDV could also improve the drug delivery efficiency and . The novel nanosystem exhibited enhanced tumor killing efficacy and improved safety compared with traditional PDT and ferroptosis therapy.
用于癌症治疗的光动力和铁死亡疗法受到癌细胞中氧气和铁的稀缺以及递药系统结构复杂的限制。在此，一种源自红细胞的载体（RDV）内在地富含血红蛋白，共同递送入癌细胞的光敏剂 Ce6 和铁死亡促进剂索拉非尼（SRF），以增强 PDT 和更强的铁死亡治疗。局部照射下 RDV 膜的损伤导致 SRF 在肿瘤部位释放，实现肿瘤靶向治疗。RDV 的脂质膜还可以提高药物递送效率。与传统 PDT 和铁死亡疗法相比，该新型纳米系统显示出增强的肿瘤杀伤效力和提高的安全性。
