Zhang Yuanyuan, Chen Qian, Zhu Yefei, Pei Manman, Wang Kairuo, Qu Xiao, Zhang Yang, Gao Jie, Qin Huanlong
Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital, School of Medicine Tongji University Shanghai China.
Precision Medicine Center Taizhou Central Hospital Taizhou Zhejiang China.
MedComm (2020). 2022 Dec 8;3(4):e192. doi: 10.1002/mco2.192. eCollection 2022 Dec.
Inorganic nanoparticles have extensively revolutionized the effectiveness of cancer therapeutics due to their distinct physicochemical properties. However, the therapeutic efficiency of inorganic nanoparticles is greatly hampered by the complex tumor microenvironment, patient heterogeneity, and systemic nonspecific toxicity. The biomimetic technology based on biological membranes (cell- or bacteria-derived membranes) is a promising strategy to confer unique characteristics to inorganic nanoparticles, such as superior biocompatibility, prolonged circulation time, immunogenicity, homologous tumor targeting, and flexible engineering approaches on the surface, resulting in the enhanced therapeutic efficacy of inorganic nanoparticles against cancer. Therefore, a greater push toward developing biomimetic-based nanotechnology could increase the specificity and potency of inorganic nanoparticles for effective cancer treatment. In this review, we summarize the recent advances in biological membrane-coated inorganic nanoparticles in cancer precise therapy and highlight the different types of engineered approaches, applications, mechanisms, and future perspectives. The surface engineering of biological membrane can greatly enhance their targeting, intelligence, and functionality, thereby realizing stronger tumor therapy effects. Further advances in materials science, biomedicine, and oncology can facilitate the clinical translation of biological membrane-coated inorganic nanoparticles.
无机纳米粒子因其独特的物理化学性质，极大地革新了癌症治疗的效果。然而，无机纳米粒子的治疗效率受到复杂的肿瘤微环境、患者异质性和全身非特异性毒性的严重阻碍。基于生物膜（细胞或细菌衍生膜）的仿生技术是一种很有前景的策略，可为无机纳米粒子赋予独特特性，如卓越的生物相容性、延长的循环时间、免疫原性、同源肿瘤靶向性以及表面灵活的工程化方法，从而提高无机纳米粒子对癌症的治疗效果。因此，大力推动基于仿生的纳米技术发展，可提高无机纳米粒子用于有效癌症治疗的特异性和效力。在本综述中，我们总结了生物膜包覆无机纳米粒子在癌症精准治疗方面的最新进展，并重点介绍了不同类型的工程化方法、应用、机制及未来展望。生物膜的表面工程可极大增强其靶向性、智能性和功能性，从而实现更强的肿瘤治疗效果。材料科学、生物医学和肿瘤学的进一步发展可促进生物膜包覆无机纳米粒子的临床转化。
