Ph 阳性慢性髓性白血病中的 14 号染色体长臂增加
14q+ in Ph-positive chronic myelogenous leukemia.
作者信息
Ohyashiki K, Ohtaki K, Ohyashiki J H, Yoshida M A, Sandberg A A
出版信息
Cancer Genet Cytogenet. 1986 Jul;22(3):257-63. doi: 10.1016/0165-4608(86)90162-7.
PMID:3458524
Abstract
Two cases of chronic myelogenous leukemia with a Ph translocation and an additional chromosome change of the long arm of a chromosome #14 (14q+) are reported. The breakpoints on chromosome #14 were identified as 14q24 and 14q32, respectively. One of the patients did not show any evidence of blastic transformation; the other patient developed a myeloid blastic crisis when the abnormal 14q+ was seen in the bone marrow cells.
摘要
报告了两例慢性粒细胞白血病患者，其存在费城染色体易位以及14号染色体长臂的额外染色体改变（14q+）。14号染色体上的断点分别定位于14q24和14q32。其中一名患者未显示任何原始细胞转化的证据；另一名患者在骨髓细胞中出现异常14q+时发生了髓系原始细胞危象。
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