Hayashi R, Ochiai T
Cancer Res. 1986 Jul;46(7):3701-3.
We studied HLA typing of 17 stage III gastric cancer patients who survived for more than 5 years after gastrectomy, in comparison with normal healthy controls and other gastric cancer patients. As a result, the long-term survivors had a high frequency of HLA-DR4 antigen compared with normal healthy controls (P less than 0.0025). This remains statistically significant after correction of the P value according to the number of HLA-DR antigens tested (corrected P value, less than 0.025), strongly suggesting that the presence of this antigen is associated with long-term survival time for postoperative stage III gastric cancer patients.
我们研究了17例III期胃癌患者的HLA分型，这些患者在胃切除术后存活超过5年，并与正常健康对照者及其他胃癌患者进行比较。结果显示，与正常健康对照者相比，长期存活者中HLA-DR4抗原的频率较高（P<0.0025）。根据所检测的HLA-DR抗原数量对P值进行校正后，这一差异仍具有统计学意义（校正后的P值<0.025），强烈提示该抗原的存在与III期胃癌患者术后的长期生存时间相关。
