Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S
Gastroenterology. 1982 Mar;82(3):413-8.
The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was of significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% of the patients vs. 31% of controls [chi 2 = 13.4, p less than 0.001, corrected p less than 0.01, relative risk = 5.1). In addition, an increased frequency of HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (chi 2 = 10.84, p less than 0.001).
对40名日本溃疡性结肠炎患者的人类淋巴细胞DR抗原以及人类淋巴细胞A、B和C抗原的频率偏差进行了评估，并与51名种族匹配的健康日本人进行了比较。溃疡性结肠炎患者中频率显著更高的抗原是HLA - DR2。该抗原在70%的患者中发现，而对照组为31%（卡方 = 13.4，p < 0.001，校正p < 0.01，相对风险 = 5.1）。此外，在日本人群中最常见的单倍型HLA - B5 - DR2在55%的溃疡性结肠炎患者中频率增加，而对照组为22%（卡方 = 10.84，p < 0.001）。
