一种源自HH-01的新型环戊烯酮衍生物。

A new cyclopentenone derivative from HH-01.

作者信息

Zhu Li, Wang Jia-Peng, Hao Feng, Gan Dong, Zhang Xiao-Ran, Li Chen-Zhe, Wang Cheng-Yao, Zhang Liang, Cai Le

机构信息

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan, Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, P.R. China.

Yunnan University Hospital, Yunnan University, Kunming, P.R. China.

出版信息

Nat Prod Res. 2023 Apr;37(7):1205-1211. doi: 10.1080/14786419.2021.1984912. Epub 2021 Sep 29.

DOI:10.1080/14786419.2021.1984912

PMID:34585648

Abstract

A new cyclopentenone derivative, atrovinol (), together with ten known compounds () were isolated from HH-01, an endophytic fungus from (Hernandiaceae). Their structures were identified by HRESIMS, 1 D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound exhibited moderate inhibitory activity against and with MIC values of 8.0 µg/mL and 16.0 µg/mL, respectively.

摘要

从莲叶桐科植物的一种内生真菌HH-01中分离出一种新的环戊烯酮衍生物阿托维诺醇（）以及十种已知化合物（）。通过高分辨电喷雾电离质谱（HRESIMS）、一维/二维核磁共振（1D/2D NMR）和电子圆二色光谱（ECD）对其结构进行了鉴定。化合物对[具体微生物1]和[具体微生物2]表现出中等抑制活性，其最低抑菌浓度（MIC）值分别为8.0μg/mL和16.0μg/mL。