Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China.
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Nat Prod Res. 2021 Nov;35(21):3772-3779. doi: 10.1080/14786419.2020.1737053. Epub 2020 Mar 11.
Three new cyclopentenoneacrylic acid derivatives, trichodermacid A (), trichodermester A (), and trichodermester B (), together with thirteen known compounds, were isolated from an ethyl acetate extract of H548, a fungus derived from mangrove sediment. The structures of the new compounds were elucidated by spectroscopic methods including HR ESI-MS, H NMR, C NMR, and 2D-NMR techniques. The antifungal activity of the isolated compounds was evaluated against tea pathogenic fungus . Trichodermester A () showed potent anti activity with MIC of 125 μg/disc, while the other compounds were inactive.
从红树林沉积物来源真菌 H548 的乙酸乙酯提取物中分离得到三个新的环戊烯酮丙烯酸衍生物，即 Trichodermacid A ()、Trichodermester A () 和 Trichodermester B ()，以及十三个已知化合物。通过包括高分辨电喷雾电离质谱（HR ESI-MS）、H NMR、C NMR 和 2D-NMR 技术在内的光谱方法阐明了新化合物的结构。对分离得到的化合物进行了抗茶病原菌的活性评估。Trichodermester A () 显示出较强的抗 活性，MIC 为 125μg/disc，而其他化合物则没有活性。
