Doi T, Nishiura T, Deguchi K, Kondo M
Chemotherapy. 1986;32(3):299-304. doi: 10.1159/000238427.
The clinical efficacy of the combination therapy with cefmenoxime plus cefsulodin was studied in patients with complicated urinary tract infections caused by Pseudomonas aeruginosa. Patients received 1 g of CMX and 1 g of CFS concomitantly twice a day by 1-hour intravenous drip infusion. Of a total of 127 patients who received medication, 82 patients were evaluated on the 5th day. The overall clinical efficacy of treatment was evaluated by the criteria proposed by the UTI Committee, Japan, as excellent, moderate or poor. It was excellent in 15%, moderate in 55% and poor in 30%. Of the 143 strains isolated from 82 patients, 115 strains (80%) were eradicated. The eradication rate of P. aeruginosa was 83%. Subjective side effects were observed in 3 (2.4%) of the patients. Drug-related aggravations in laboratory test results were observed in 8 (7.5%), but most of them were minimal and reversible. The results of this study suggest that a combination of cefmenoxime and cefsulodin might be useful in the treatment of complicated urinary tract infections caused by P. aeruginosa.
研究了头孢甲肟联合磺苄西林治疗铜绿假单胞菌所致复杂性尿路感染患者的临床疗效。患者每日两次同时接受1g头孢甲肟和1g磺苄西林，通过1小时静脉滴注给药。在总共127例接受治疗的患者中，82例患者在第5天进行了评估。根据日本UTI委员会提出的标准评估治疗的总体临床疗效，分为优、中、差。疗效为优的占15%，中等的占55%，差的占30%。从82例患者中分离出143株菌株，其中115株（80%）被清除。铜绿假单胞菌的清除率为83%。3例（2.4%）患者观察到主观副作用。8例（7.5%）患者观察到与药物相关的实验室检查结果加重，但大多数为轻微且可逆的。本研究结果表明，头孢甲肟和磺苄西林联合使用可能对治疗铜绿假单胞菌所致复杂性尿路感染有效。
