铜（II）介导的色氨酸C-H硫苯基化或硒苯基化实现肽的大环化。

Copper(II)-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides.

作者信息

Kobayashi Daishiro, Kohmura Yutaka, Hayashi Junya, Denda Masaya, Tsuchiya Koichiro, Otaka Akira

机构信息

Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University, Sho-machi, 1-78-1, Tokushima 770-8505, Japan.

出版信息

Chem Commun (Camb). 2021 Oct 14;57(82):10763-10766. doi: 10.1039/d1cc04856b.

DOI:10.1039/d1cc04856b

PMID:34585682

Abstract

Cu(II)-mediated C-H sulphenylation or selenylation of Trp indole by a derivative of cysteine or selenocysteine enables access to the tryptathionine unit or its selenium congener. The mechanism of these protocols, which allow macrocyclization of Trp-containing peptides, has been studied.

摘要

铜（II）介导的半胱氨酸或硒代半胱氨酸衍生物对色氨酸吲哚的C-H硫苯基化或硒苯基化反应能够合成色硫辛单元或其含硒类似物。人们已经对这些可实现含色氨酸肽大环化的反应机理进行了研究。