Senior Professor, Government Medical College, Kota, Rajasthan.
Senior Resident, Government Medical College, Kota, Rajasthan; Corresponding Author.
J Assoc Physicians India. 2021 Sep;69(9):11-12.
Diabetes mellitus is a chronic debilitating illness associated with several complications of which hypogonadism in male patients with type 2 diabetes mellitus (T2DM) is often overlooked but carries a high prevalence and possibly associated with several co-morbidities.
To study the correlation of serum testosterone with clinical and biochemical factors in male patients with type 2 diabetes mellitus.
In our cross-sectional study, we selected a group of 100 patients with type 2 diabetes mellitus (50 each with hypogonadism and 50 with eugonadism) and obtained their biochemical parameters and looked for the prevalence of co-morbid conditions. We did a correlation of serum testosterone with each quantitative variable using Pearson's Coefficient of correlation and multivariable logistic regression analysis was applied.
Serum testosterone levels were found to be correlated with age, waist circumference, fasting blood sugar, serum triglycerides and eGFR (p<0.05).The prevalence of coronary artery disease was higher in T2DM male patients with hypogonadism as compared eugonadal patients. We found higher odds (1.33 times) for coronary artery disease in male patients with hypogonadism and T2DM as compared to males with T2DM and eugonadism.
There is a higher risk of coronary artery disease in male patients with T2DM and hypogonadism as compared to males with T2DM and eugonadal status.
糖尿病是一种慢性衰弱性疾病，与多种并发症相关，其中男性 2 型糖尿病患者的性腺功能减退症常常被忽视，但患病率较高，可能与多种合并症相关。
研究血清睾酮与男性 2 型糖尿病患者临床和生化因素的相关性。
在我们的横断面研究中，我们选择了 100 名 2 型糖尿病患者（每组 50 名性腺功能减退症和 50 名性腺功能正常），并获得了他们的生化参数，并寻找合并症的患病率。我们使用 Pearson 相关系数对血清睾酮与每个定量变量进行了相关性分析，并应用多元逻辑回归分析。
血清睾酮水平与年龄、腰围、空腹血糖、血清甘油三酯和 eGFR 相关（p<0.05）。性腺功能减退症的 2 型糖尿病男性患者患冠状动脉疾病的患病率较高。与性腺功能正常的 2 型糖尿病男性患者相比，我们发现性腺功能减退症和 2 型糖尿病男性患者患冠状动脉疾病的几率更高（1.33 倍）。
与性腺功能正常的 2 型糖尿病男性患者相比，性腺功能减退症和 2 型糖尿病男性患者患冠状动脉疾病的风险更高。
