Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Periodontology, Porto Alegre, RS, Brazil.
Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Oral Surgery and Periodontology, Ribeirão Preto, SP, Brazil.
Braz Oral Res. 2021 Sep 24;35(Supp 2):e095. doi: 10.1590/1807-3107bor-2021.vol35.0095. eCollection 2021.
The aim of this review was to update the evidence of new approaches to non-surgical therapy (NSPT) in the treatment of periodontitis. Preclinical and clinical studies addressing the benefits of adjunctive antimicrobial photodynamic therapy, probiotics, prebiotics/synbiotics, statins, pro-resolving mediators, omega-6 and -3, ozone, and epigenetic therapy were scrutinized and discussed. Currently, the outcomes of these nine new approaches, when compared with subgingival debridement alone, did not demonstrate a significant added clinical benefit. However, some of these new alternative interventions may have the potential to improve the outcomes of NSPT alone. Future evidence based on randomized controlled clinical trials would help clinicians and patients in the selection of different adjunctive therapies.
本次综述旨在更新牙周炎非手术治疗（NSPT）新方法的证据。本文对辅助抗菌光动力疗法、益生菌、益生元/合生剂、他汀类药物、促解决介质、ω-6 和 ω-3、臭氧和表观遗传学治疗的临床前和临床研究进行了审查和讨论。目前，与单独龈下刮治相比，这 9 种新方法的结果并未显示出显著的临床附加益处。然而，这些新的替代干预措施中的一些可能有潜力改善 NSPT 的单独治疗效果。基于随机对照临床试验的未来证据将有助于临床医生和患者选择不同的辅助治疗方法。
