Pardo Alessia, Signoriello Annarita, Brancato Gabriele, Brancato Raffaele, Messina Elena, Faccioni Paolo, Marcoccia Stefano, Nardi Gianna Maria, Lombardo Giorgio
Dentistry and Maxillo-Facial Surgery Unit, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Dentistry Unit, Department of Surgery, Mater Salutis Hospital, Via Gianella 1, 37045 Legnago, Italy.
J Clin Med. 2025 Jul 18;14(14):5124. doi: 10.3390/jcm14145124.
Additional therapies (e.g., laser, photodynamic therapy, and ozone) have been reported to improve mechanical instrumentation and immune response in non-surgical periodontal therapy (NSPT). With this systematic review we evaluated the effectiveness of ozone therapy in reducing inflammation and progression of periodontal disease. Three electronic databases (PubMed, Scopus, and Cochrane Library) were searched for randomized and clinical trials on ozone therapy (gas, liquid, gel/oil) combined with NSPT. The study design followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and the risk of bias was assessed using the RoB-2 tool. Eight of the twenty-two studies reviewed reported on gaseous ozone, nine on ozone water, and five on ozonated oil/gel as an adjunct to mechanical periodontal instrumentation, often with scaling and root planing (SRP). Ozone was found to be more effective than SRP alone in treating inflammation, as measured with the gingival index (VMD -0.32; 95% confidence interval (CI) (-0.41; -0.24); < 0.00001) and compared to chlorhexidine (CHX) (ozone gel; VMD -0.10; 95% CI (-0.20; -0.01); = 0.03). The study findings were inconsistent, however, with several reporting clinical and microbiological benefit while others observed no marked improvement with the addition of ozone therapy to NSPT. While ozone therapy may represent a useful adjunct to NSPT, further research with larger study groups is warranted to determine its effectiveness.
据报道，额外的治疗方法（如激光、光动力疗法和臭氧）可改善非手术牙周治疗（NSPT）中的机械清创和免疫反应。通过本系统评价，我们评估了臭氧疗法在减轻牙周炎炎症和疾病进展方面的有效性。检索了三个电子数据库（PubMed、Scopus和Cochrane图书馆），以查找关于臭氧疗法（气体、液体、凝胶/油）联合NSPT的随机临床试验。研究设计遵循2020年系统评价和Meta分析的首选报告项目（PRISMA）指南，并使用RoB-2工具评估偏倚风险。在纳入综述的22项研究中，8项报告了气态臭氧，9项报告了臭氧水，5项报告了臭氧化油/凝胶作为机械牙周清创（通常伴有龈下刮治和根面平整（SRP））的辅助手段。与单独的SRP相比，臭氧在治疗炎症方面更有效，以牙龈指数衡量（平均差（VMD）为-0.32；95%置信区间（CI）为（-0.41；-0.24）；P<0.00001），与氯己定（CHX）相比（臭氧凝胶；VMD为-0.10；95%CI为（-0.20；-0.01）；P = 0.03）。然而，研究结果并不一致，一些研究报告了临床和微生物学方面的益处，而另一些研究则观察到在NSPT中添加臭氧疗法并没有显著改善。虽然臭氧疗法可能是NSPT的一种有用辅助手段，但需要更大规模的研究组进行进一步研究以确定其有效性。
