Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Department of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Hum Brain Mapp. 2021 Dec 15;42(18):6028-6037. doi: 10.1002/hbm.25667. Epub 2021 Sep 29.
It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.
有人假设，双相情感障碍 (BD) 的遗传风险越高，创造力就越强。鉴于双相情感障碍的临床重要性以及创造力对人类社会和文化发展的重要性，揭示其相关性和双相情感障碍遗传风险的神经基础对于深入了解其病因至关重要。然而，尽管之前已经证明了 BD 的多基因风险评分 (PRS) 与创造性职业之间存在关联，但 BD-PRS 与创造力之间的关联，即发散思维 (CMDT) 和区域灰质体积 (rGMV) 以及区域白质体积 (rWMV) 的测量，尚未得到研究。使用心理分析和全脑体素分析，我们在 1558 名年轻、发育正常的成年学生中研究了这些潜在的关联。在调整了混杂变量和多次比较后，更大的 BD-PRS 与更大的总 CMDT 流畅性评分相关，并且在流畅性子评分中发现了显著的关系。更大的 BD-PRS 也与更低的总情绪困扰相关。神经影像学分析表明，BD-PRS 与右侧额下回的 rGMV 更大相关，而右侧额下回是 BD 中一致受影响的区域，与左侧额中回的 rWMV 更大相关，左侧额中回被认为在与 BD 相关的创造力增加的风险中发挥核心作用。这些发现表明，在年轻的受过教育的个体中，BD 的遗传风险与 CMDT 和前额皮质结构之间存在关系。
