Takeuchi Hikaru, Taki Yasuyuki, Nouchi Rui, Yokoyama Ryoichi, Kotozaki Yuka, Nakagawa Seishu, Sekiguchi Atsushi, Iizuka Kunio, Yamamoto Yuki, Hanawa Sugiko, Araki Tsuyoshi, Makoto Miyauchi Carlos, Shinada Takamitsu, Sakaki Kohei, Sassa Yuko, Nozawa Takayuki, Ikeda Shigeyuki, Yokota Susumu, Daniele Magistro, Kawashima Ryuta
Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Hum Brain Mapp. 2017 Jan;38(1):414-430. doi: 10.1002/hbm.23369. Epub 2016 Sep 20.
The importance of brain connectivity for creativity has been theoretically suggested and empirically demonstrated. Studies have shown sex differences in creativity measured by divergent thinking (CMDT) as well as sex differences in the structural correlates of CMDT. However, the relationships between regional white matter volume (rWMV) and CMDT and associated sex differences have never been directly investigated. In addition, structural studies have shown poor replicability and inaccuracy of multiple comparisons over the whole brain. To address these issues, we used the data from a large sample of healthy young adults (776 males and 560 females; mean age: 20.8 years, SD = 0.8). We investigated the relationship between CMDT and WMV using the newest version of voxel-based morphometry (VBM). We corrected for multiple comparisons over whole brain using the permutation-based method, which is known to be quite accurate and robust. Significant positive correlations between rWMV and CMDT scores were observed in widespread areas below the neocortex specifically in females. These associations with CMDT were not observed in analyses of fractional anisotropy using diffusion tensor imaging. Using rigorous methods, our findings further supported the importance of brain connectivity for creativity as well as its female-specific association. Hum Brain Mapp 38:414-430, 2017. © 2016 Wiley Periodicals, Inc.
大脑连通性对创造力的重要性已在理论上得到提示，并在实证上得到证明。研究表明，在通过发散思维测量的创造力（CMDT）方面存在性别差异，以及在CMDT的结构相关性方面存在性别差异。然而，区域白质体积（rWMV）与CMDT之间的关系以及相关的性别差异从未被直接研究过。此外，结构研究表明，全脑多次比较的可重复性差且不准确。为了解决这些问题，我们使用了来自大量健康年轻成年人样本（776名男性和560名女性；平均年龄：20.8岁，标准差 = 0.8）的数据。我们使用最新版本的基于体素的形态测量法（VBM）研究了CMDT与WMV之间的关系。我们使用基于排列的方法对全脑多次比较进行校正，该方法已知相当准确且稳健。在新皮层以下的广泛区域，特别是在女性中，观察到rWMV与CMDT分数之间存在显著正相关。在使用扩散张量成像的分数各向异性分析中未观察到这些与CMDT的关联。通过严格的方法，我们的研究结果进一步支持了大脑连通性对创造力的重要性及其女性特异性关联。《人类大脑图谱》38:414 - 430, 2017。© 2016威利期刊公司。
