Department of General Surgery, Wuhan Xinzhou District Hospital of Traditional Chinese Medicine, Wuhan, China.
Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Crit Rev Eukaryot Gene Expr. 2021;31(4):9-20. doi: 10.1615/CritRevEukaryotGeneExpr.2021038597.
Long intergenic non-protein coding RNA has an important biological role in tumors. But, LINC01140 in sarcoma has not been studied yet. This study investigates the expression and prognosis role of LINC01140 in sarcoma. LINC01140 was lower in metastatic sarcoma, and low LINC01140 expression predicted poor overall survival, disease-free survival, and disease-specific survival in sarcoma. High LINC01140 expression and radiotherapy could promote survival of sarcoma. Gene set enrichment analysis showed LINC01140 was involved in interferon-gamma response, epithelial-mesenchymal transition, the interaction between cytokine receptors, and cholesterol homeostasis. Gene ontology enrichment analysis showed LINC01140 was involved in immunity, fatty acid metabolism, amino acid metabolism, cell division, serine/threonine-protein kinase. LINC01140 expression was negatively correlated with various epithelial-mesenchymal transition factors and positively correlated with the expression of anti-cancer factor hypermethylated-in-cancer 1. These results confirmed that LINC01140 may be a potential novel prognostic molecule in sarcoma.
长链非编码 RNA 在肿瘤中有重要的生物学作用。然而，肉瘤中的 LINC01140 尚未被研究过。本研究调查了 LINC01140 在肉瘤中的表达和预后作用。转移性肉瘤中 LINC01140 的表达降低，低表达 LINC01140 预示着肉瘤患者总生存期、无病生存期和疾病特异性生存期较差。高 LINC01140 表达和放疗可促进肉瘤的生存。基因集富集分析显示 LINC01140 参与了干扰素-γ反应、上皮-间质转化、细胞因子受体相互作用和胆固醇稳态。基因本体论富集分析表明 LINC01140 参与了免疫、脂肪酸代谢、氨基酸代谢、细胞分裂、丝氨酸/苏氨酸蛋白激酶。LINC01140 的表达与各种上皮-间质转化因子呈负相关，与抗癌因子高甲基化癌 1 的表达呈正相关。这些结果证实，LINC01140 可能是肉瘤中一种潜在的新型预后分子。
