Li Deheng, Li Liangdong, Cao Yiqun, Chen Xin
Department of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
Oncol Lett. 2020 Feb;19(2):1157-1164. doi: 10.3892/ol.2019.11147. Epub 2019 Nov 25.
Breast cancer (BC) is one of the most dangerous malignant diseases among women. A growing amount of evidence has suggested that long non-coding RNAs participate in the development and progression of BC and may potentially serve as therapeutic targets or prognostic markers for the disease. A previous study demonstrated that long intergenic non-protein coding RNA 01140 (LINC01140) was prominently correlated with overall survival in patients with gastric cancer. However, the function of LINC01140 in BC has not yet been elucidated. Therefore, the present study aimed to investigate the roles and molecular mechanisms underlying LINC01140 in BC. LINC01140 expression in 1,085 breast cancer patients and 291 healthy subjects was analyzed from the Gene Expression Profiling Interactive Analysis website. The association between LINC01140 expression and T stages, LINC01140-related biological pathways, and the correlation between LINC01140 expression genes were also analyzed in 825 patients with BC through the cBioPortal database. The present study demonstrated that LINC01140 expression was significantly decreased in the tumor samples compared with normal samples in patients with BC (P<0.05). The present study revealed that LINC01140 expression was significantly decreased in the T4 stage compared with T1, T2 or T3 stage (P<0.01). In addition, high expression levels of LINC01140 predicts longer relapse-free survival probability in patients with BC. It was also observed that LINC01140 participates in a variety of biological pathways, particularly in the epithelial-to-mesenchymal transition. The co-expression relationship between the LINC01140 and an abundance of genes in samples from the BC study was investigated. These genes, such as and , participate in the development and progression of tumor growth and bone metastasis. Finally, the present study observed the interaction between microRNA (miR)-200b and miR-200c with LINC011440. The results from the present study indicated that higher expression of LINC01140 was beneficial for patients with BC. LINC01140 may be a potential biomarker for the prognosis of patients with BC. The role of LINC01140 in BC needs to be further evaluated.
乳腺癌（BC）是女性中最危险的恶性疾病之一。越来越多的证据表明，长链非编码RNA参与了BC的发生和发展，并且可能作为该疾病的治疗靶点或预后标志物。先前的一项研究表明，长链基因间非编码RNA01140（LINC01140）与胃癌患者的总生存期显著相关。然而，LINC01140在BC中的功能尚未阐明。因此，本研究旨在探讨LINC01140在BC中的作用及其分子机制。通过基因表达谱交互式分析网站分析了1085例乳腺癌患者和291例健康受试者中LINC01140的表达情况。还通过cBioPortal数据库分析了825例BC患者中LINC01140表达与T分期、LINC01140相关生物途径以及LINC01140表达基因之间的相关性。本研究表明，与BC患者的正常样本相比，肿瘤样本中LINC01140的表达显著降低（P<0.05）。本研究显示，与T1、T2或T3期相比，T4期LINC01140的表达显著降低（P<0.01）。此外，LINC01140的高表达预示着BC患者更长的无复发生存概率。还观察到LINC01140参与多种生物途径，特别是上皮-间质转化。研究了BC研究样本中LINC01140与大量基因之间的共表达关系。这些基因，如 和 ，参与肿瘤生长和骨转移的发生和发展。最后，本研究观察了微小RNA（miR）-200b和miR-200c与LINC011440之间的相互作用。本研究结果表明，LINC01140的高表达对BC患者有益。LINC01140可能是BC患者预后的潜在生物标志物。LINC01140在BC中的作用有待进一步评估。
