Ten Barış, Kaya Tamer İrfan, Balcı Yüksel, Esen Kaan, Temel Gülhan, Türsen Ümit, Yılmaz Mustafa Anıl
Department of Radiology, Mersin University Faculty of Medicine, Mersin, Turkey.
Department of Dermatology, Mersin University Faculty of Medicine, Mersin, Turkey.
J Cosmet Dermatol. 2022 Jul;21(7):2962-2970. doi: 10.1111/jocd.14488. Epub 2021 Sep 29.
Androgenetic alopecia (AGA) is the most common cause of hair loss in males. Physical examination and history are the most important examinations in diagnosis of the disease. As yet, there is no diagnostic method to be able to determine which individuals will develop AGA. Shear-wave elastography (SWE) is a novel diagnostic tool, which can evaluate tissue stiffness. Superb microvascular imaging (SMI) can determine low flow in microvessels. The aim of the current study was to determine whether or not AGA would develop in individuals with normal hair and a family history of AGA using B-mode US, SMI, and SWE.
The study included 26 patients clinically diagnosed with AGA and a control group of 26 volunteers.
Thickness with the distance from the epidermis to the calvarium (ECD) on the hairline and cranial subcutaneous tissue thickness (CSTD) were determined to be statistically significantly thinner in the AGA group than in the control group (p < 0.0001). For the differentiation of the AGA patients, the cutoff value was determined to be 5.5 mm for ECD and 4.05 mm for CSTD. The cranial epidermis-dermis (CED) stiffness values both as meter/second (m/s) and kilopascals (kPa) were statistically significantly lower in the AGA patients than in the control group (p < 0.0001). The cutoff values were 6.075 as m/s and 104.4 as kPa.
The results of this study demonstrated that differentiation could be made of individuals before the development of AGA from normal healthy individuals with CSTD measurement on B-mode US and CED stiffness measurement on SWE.
雄激素性脱发（AGA）是男性脱发最常见的原因。体格检查和病史是该疾病诊断中最重要的检查。迄今为止，尚无能够确定哪些个体将会发生AGA的诊断方法。剪切波弹性成像（SWE）是一种新型诊断工具，可评估组织硬度。超微血管成像（SMI）能够测定微血管中的低血流。本研究的目的是使用B超、SMI和SWE来确定有AGA家族史且头发正常的个体是否会发生AGA。
该研究纳入了26例临床诊断为AGA的患者以及一个由26名志愿者组成的对照组。
确定AGA组发际线处从表皮到颅骨的厚度（ECD）以及颅骨皮下组织厚度（CSTD）在统计学上显著薄于对照组（p < 0.0001）。对于AGA患者的鉴别，ECD的临界值确定为5.5毫米，CSTD的临界值确定为4.05毫米。AGA患者的颅骨表皮-真皮（CED）硬度值，无论是以米/秒（m/s）还是千帕斯卡（kPa）为单位，在统计学上均显著低于对照组（p < 0.0001）。临界值分别为6.075 m/s和104.4 kPa。
本研究结果表明，通过B超测量CSTD以及SWE测量CED硬度，可在AGA发生之前将其与正常健康个体区分开来。
