Peng Yang, Janda Monika, Obermair Andreas
Faculty of Medicine, Queensland Centre for Gynaecological Cancer Research, The University of Queensland, Brisbane, Australia.
Faculty of Medicine, Centre for Health Services Research, The University of Queensland, Brisbane, Australia.
Gynecol Oncol Rep. 2020 Jun 19;33:100604. doi: 10.1016/j.gore.2020.100604. eCollection 2020 Aug.
Endometrial cancer (EC) is the fifth most common cancer in women in developed countries. Clinical practice guidelines recommend patients should be followed-up every 3-6 months after primary treatment of EC. Evidence suggests that 40% to 80% of patients develop symptoms prior to being diagnosed with EC recurrence, however which symptoms are key remains unclear. We previously conducted a comprehensive literature review and developed a questionnaire on patient-reported symptoms associated with EC recurrence. This is a brief communication on a pilot prospective cohort study among 120 Australian patients who completed primary treatment for EC in the past three years. The study showed 47 of the 120 patients (39.2%) self-reported at least one symptom, four of whom (3.3%) were diagnosed with a recurrence. Back or lumbar pain ( = 0.012), vaginal bleeding ( < 0.001), and lethargy, fatigue, exhaustion or tiredness ( = 0.002) were significantly associated with the development of EC recurrence. The checklist will be further validated as part of a randomized controlled clinical trial to confirm the observed relationship between symptoms and the development of EC recurrence.
子宫内膜癌（EC）是发达国家女性中第五大常见癌症。临床实践指南建议，子宫内膜癌患者在接受初次治疗后应每3至6个月进行一次随访。有证据表明，40%至80%的患者在被诊断为子宫内膜癌复发之前会出现症状，然而哪些症状是关键症状仍不清楚。我们之前进行了一项全面的文献综述，并编制了一份关于患者报告的与子宫内膜癌复发相关症状的问卷。这是一篇简短的通讯，内容是关于一项针对120名澳大利亚患者的前瞻性队列研究试点，这些患者在过去三年中完成了子宫内膜癌的初次治疗。研究显示，120名患者中有47名（39.2%）自我报告至少出现了一种症状，其中4名（3.3%）被诊断为复发。背部或腰部疼痛（P = 0.012）、阴道出血（P < 0.001）以及无精打采、疲劳、精疲力竭或疲倦（P = 0.002）与子宫内膜癌复发的发生显著相关。该清单将作为一项随机对照临床试验的一部分进行进一步验证，以确认所观察到的症状与子宫内膜癌复发发生之间的关系。
