Zhejiang Chinese Medical University, Hangzhou, China.
Department of Otolaryngology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Eur Arch Otorhinolaryngol. 2022 May;279(5):2223-2230. doi: 10.1007/s00405-021-07108-6. Epub 2021 Sep 29.
Tubomanometry (TMM) and the seven-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7) was integrated to establish the Tubomanometry Eustachian Tube Dysfunction Questionnaire (T-ETDQ), and its reliability, potential clinical application, and diagnostic value for Eustachian tube function were investigated.
This prospective diagnostic study included patients visiting the ENT Department of our Hospital, between April and June 2021. Patients were grouped into Eustachian tube dysfunction (ETD) and control groups according to tympanometry diagnosis results. The diagnostic value of the T-ETDQ was evaluated using receiver-operating characteristic (ROC) curve analysis.
There were 48 patients with Obstructive ETD and 24 patients without. The area under the ROC curve (AUC) of T-ETDQ was 0.898 (95% confidence interval [CI] 0.826-0.969), and the highest sensitivity and specificity were 76.7% and 86.7% respectively when the positive cutoff value was 4.72. The AUC of Eustachian tube score (ETS) was 0.731 (95% CI 0.625-0.837) and the highest sensitivity and specificity were 48.3% and 90.0% respectively when the positive cut-off value was 4.5. The ETS and T-ETDQ had kappa values of 0.311 and 0.585, respectively (P < 0.001 for both), showing both methods were comparable to tympanometry; however, T-ETDQ had more consistent results than ETS.
T-ETDQ can effectively quantify and evaluate ETD severity in adults, has a higher diagnostic value than ETS, making it a suitable diagnostic tool.
通过将管内压测量（TMM）和七项咽鼓管功能障碍问卷（ETDQ-7）整合建立管内压咽鼓管功能障碍问卷（T-ETDQ），研究其信度、潜在临床应用价值及对咽鼓管功能的诊断价值。
本前瞻性诊断研究纳入 2021 年 4 月至 6 月期间在我院耳鼻喉科就诊的患者。根据鼓室压测量结果将患者分为咽鼓管功能障碍（ETD）组和对照组。采用受试者工作特征（ROC）曲线分析 T-ETDQ 的诊断价值。
共纳入 48 例阻塞性 ETD 患者和 24 例非 ETD 患者。T-ETDQ 的 ROC 曲线下面积（AUC）为 0.898（95%可信区间 [CI]：0.826-0.969），当阳性截断值为 4.72 时，其灵敏度和特异度最高分别为 76.7%和 86.7%。Eustachian 管评分（ETS）的 AUC 为 0.731（95%CI：0.625-0.837），当阳性截断值为 4.5 时，其灵敏度和特异度最高分别为 48.3%和 90.0%。ETS 和 T-ETDQ 的 Kappa 值分别为 0.311 和 0.585（均 P<0.001），表明两种方法与鼓室压测量均具有可比性，而 T-ETDQ 的结果更一致。
T-ETDQ 可有效量化和评估成人 ETD 的严重程度，其诊断价值高于 ETS，是一种合适的诊断工具。
