Department of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, North Carolina, U.S.A.
Clinical Development, Catalyst Clinical Research, Raleigh, North Carolina, 27617, U.S.A.
Laryngoscope. 2022 Nov;132(11):2217-2223. doi: 10.1002/lary.29995. Epub 2022 Jan 3.
OBJECTIVES/HYPOTHESIS: To evaluate the ability of the Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) to discriminate between patients with Eustachian tube dysfunction (ETD) and Non-ETD diagnoses, and identify symptom information to improve ability to discriminate these groups.
Cohort study.
Pilot retrospective study with consecutive adult patients presenting to otology clinics and one general otolaryngology clinic in an academic health system. Patients were administered ETDQ-7 with eight additional symptom items. Electronic health records were reviewed for demographic and diagnostic information. Patients were grouped into diagnosis categories: 1) True ETD, 2) experiencing ear fullness (EF) not due to ETD, and 3) Control patients without ETD-related disorders or EF. ETDQ-7 and symptom item scores were compared by the diagnosis group. Receiver-operative characteristics curves and area under the curve (AUC) were generated for each ETD diagnosis group based on ETDQ-7 and symptom scores.
Of the 108 patients included in this study 74 (68.5%) were diagnosed with ETD. Patients with ETD had higher (indicating worse symptom burden) overall ETDQ-7 scores than Control group (Median [Q1, Q3] 3.0, [1.7, 4.1]; versus 1.5 [1.0, 3.4] P = .008). There was no statistically significant difference between overall ETDQ-7 scores for ETD and Non-ETD EF patients (P = .389). The AUC for the ETDQ-7 in discriminating ETD from other conditions that cause EF was 0.569; the addition of 8 symptom questions to the ETDQ-7 improved AUC to 0.801.
Additional patient-reported symptom information may improve the ability to discriminate ETD from other similarly presenting diagnoses when using ETDQ-7.
3 Laryngoscope, 132:2217-2223, 2022.
目的/假设：评估咽鼓管功能障碍问卷-7（ETDQ-7）区分咽鼓管功能障碍（ETD）和非 ETD 诊断的能力，并确定症状信息以提高区分这些组别的能力。
队列研究。
在学术健康系统中的耳鼻喉科诊所和一家普通耳鼻喉科诊所进行了前瞻性试点回顾性研究。为患者提供 ETDQ-7 并附加八项额外症状项目。审查电子健康记录以获取人口统计学和诊断信息。患者被分为诊断类别：1）真性 ETD，2）经历非 ETD 引起的耳闷（EF），3）无 ETD 相关疾病或 EF 的对照患者。根据诊断组比较 ETDQ-7 和症状项目得分。根据 ETDQ-7 和症状评分，为每个 ETD 诊断组生成接收器操作特性曲线和曲线下面积（AUC）。
本研究共纳入 108 例患者，其中 74 例（68.5%）被诊断为 ETD。与对照组（中位数 [Q1，Q3] 3.0，[1.7，4.1]；与 ETD 患者的整体 ETDQ-7 评分更高（表明症状负担更重）（P = 0.008）。ETD 和非 ETD EF 患者的整体 ETDQ-7 评分无统计学差异（P = 0.389）。ETDQ-7 区分 ETD 与引起 EF 的其他情况的 AUC 为 0.569；将 8 项症状问题添加到 ETDQ-7 中可将 AUC 提高至 0.801。
当使用 ETDQ-7 时，患者报告的附加症状信息可能会提高区分 ETD 与其他类似表现诊断的能力。
3 级喉镜，132：2217-2223，2022 年。
