刺激氨基糖苷类药物摄取以杀死耐甲氧西林金黄色葡萄球菌。
Stimulating Aminoglycoside Uptake to Kill Staphylococcus aureus Persisters.
机构信息
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Methods Mol Biol. 2021;2357:223-236. doi: 10.1007/978-1-0716-1621-5_15.
Aminoglycosides are bactericidal drugs which require a proton motive force (PMF) for uptake into the bacterial cell. Low energy cells, such as persisters, maintain a PMF below the threshold for drug uptake and are tolerant to aminoglycosides. In this chapter, we discuss mechanisms to target the bacterial membrane and stimulate aminoglycoside uptake to kill Staphylococcus aureus persisters.
氨基糖苷类是杀菌药物，需要质子动力势 (PMF) 才能进入细菌细胞。低能量细胞，如持续存在菌，维持低于药物摄取阈值的 PMF，并对氨基糖苷类具有耐受性。在本章中，我们讨论了靶向细菌膜并刺激氨基糖苷类摄取以杀死金黄色葡萄球菌持续存在菌的机制。
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