Filice G A, Fraser D W
Ann Intern Med. 1978 Apr;88(4):538-42. doi: 10.7326/0003-4819-88-4-538.
We describe an approach to the management of household contacts of leprosy patients and the rationale on which it is based. Initially, all household contacts should be interviewed and examined for symptoms and signs consistent with leprosy and appropriate diagnostic measures taken. Contacts of untreated lepromatous and dimorphous (borderline) leprosy patients are at relatively high risk of disease and should be examined annually for at least 5 years. Dapsone prophylaxis has been shown to prevent secondary cases in contacts up to 25 years old and should be used in these and possibly in older persons. Insufficient data exist to support a recommendation for the use of BCG at present.
我们描述了一种麻风病患者家庭接触者的管理方法及其依据的原理。首先，应对所有家庭接触者进行访谈，并检查是否有与麻风病相符的症状和体征，同时采取适当的诊断措施。未经治疗的瘤型和二型（界线类）麻风病患者的接触者患病风险相对较高，应至少每年检查5年。已证明氨苯砜预防可防止25岁以下接触者出现二代病例，应在这些人群以及可能的年长者中使用。目前尚无足够数据支持使用卡介苗的建议。
