Jesudasan K, Bradley D, Smith P G, Christian M
Indian J Lepr. 1984 Jul-Sep;56(3):600-14.
The data consisted of information from 1,564 "Primary cases" of leprosy of all classification and 9,162 of their household contacts. Household contacts of Indeterminate (Ind), Borderline (BL) and Lepromatous (LL), "Primary case" (PC) had an incidence rate (IR) of 5 per 1000 person years of risk (PYR). Household contacts of Tuberculoid (TT) and borderline tuberculoid (BT) patients had an IR of 3.2 and 3.8 per 1000 PYR respectively. Compared with an incidence rate of leprosy of 1.6 per 1000 PYR among individuals not exposed to leprosy in the same area, household contacts of Non-lepromatous patients had a relative risk of twice as high and contacts of lepromatous and borderline lepromatous patients a relative risk of 3 times as high. The incidence rate was higher among household contacts of bacteriologically positive patients, among contacts closely related and in households with multiple cases. The peak age specific incidence rate among household contacts was between the ages 5-9 years of age. The significance of these findings are discussed.
数据包括来自1564例所有分类的麻风病“原发病例”及其9162名家庭接触者的信息。未定类(Ind)、界线类(BL)和瘤型(LL)“原发病例”(PC)的家庭接触者每1000人年风险(PYR)的发病率(IR)为5。结核样型(TT)和界线类偏结核样型(BT)患者的家庭接触者每1000 PYR的IR分别为3.2和3.8。与同一地区未接触麻风病个体中每1000 PYR的麻风病发病率1.6相比,非瘤型患者的家庭接触者相对风险高两倍,瘤型和界线类偏瘤型患者的接触者相对风险高3倍。细菌学阳性患者的家庭接触者、密切相关接触者以及有多例病例家庭中的接触者发病率更高。家庭接触者中特定年龄发病率高峰在5至9岁之间。讨论了这些发现的意义。