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儿童呼吸道合胞病毒感染及其与气候和环境因素的相关性。

Respiratory syncytial virus infection in children and its correlation with climatic and environmental factors.

机构信息

Department of Respiration, Children's Hospital of Soochow University, Suzhou, China.

Department of Pediatrics, The Second Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

J Int Med Res. 2021 Sep;49(9):3000605211044593. doi: 10.1177/03000605211044593.

DOI:10.1177/03000605211044593
PMID:34590875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8489770/
Abstract

OBJECTIVE

In this study, we aimed to investigate the clinical epidemiology of lower respiratory tract infections with different respiratory syncytial virus (RSV) subtypes in hospitalized children in Suzhou and their correlation with climatic and environmental factors.

METHOD

In this retrospective cross-sectional study, we collected nasopharyngeal secretion samples from children hospitalized with acute lower respiratory tract infection. We collected the clinical data of children with RSV infection, and compared and analyzed their epidemiological characteristics.

RESULTS

RSV-B was the dominant strain in 2016. In 2018, RSV-A was the dominant strain. The positive detection rate of RSV-A was negatively correlated with monthly mean temperature, monthly mean wind speed, total monthly rainfall, and O concentration and positively correlated with PM2.5, PM10, and NO, SO, and CO concentrations. The positive detection rate of RSV-B was negatively correlated with monthly average temperature, monthly total rainfall, monthly sunshine duration, and O concentration and positively correlated with CO concentration.

CONCLUSIONS

RSV-A was the main subtype detected in this study. The positive detection rate of RSV-A was related to temperature, wind speed, rainfall, PM2.5. PM10, and NO, SO, CO, and O concentrations. The positive detection rate of RSV-B was related to temperature, rainfall, sunshine time, and O concentration.

摘要

目的

本研究旨在探讨苏州地区住院儿童下呼吸道感染不同呼吸道合胞病毒（RSV）亚型的临床流行病学特征及其与气候和环境因素的相关性。

方法

采用回顾性病例对照研究方法，收集苏州地区急性下呼吸道感染住院患儿的鼻咽分泌物标本，采集 RSV 感染患儿的临床资料，比较分析其流行病学特征。

结果

2016 年 RSV-B 为优势株，2018 年 RSV-A 为优势株。RSV-A 的阳性检出率与月平均气温、月平均风速、月总降雨量、O3浓度呈负相关，与 PM2.5、PM10、NO、SO2、CO 浓度呈正相关。RSV-B 的阳性检出率与月平均气温、月总降雨量、月日照时间、O3浓度呈负相关，与 CO 浓度呈正相关。

结论

本研究主要检测到 RSV-A 为优势亚型。RSV-A 的阳性检出率与温度、风速、降雨量、PM2.5、PM10、NO、SO2、CO 浓度有关。RSV-B 的阳性检出率与温度、降雨量、日照时间和 O3浓度有关。

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