Guérineau Nathalie C, Monteil Arnaud, Lory Philippe
IGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France; LabEx "Ion Channels Science and Therapeutics", Montpellier, France.
IGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France; LabEx "Ion Channels Science and Therapeutics", Montpellier, France.
Front Neuroendocrinol. 2021 Oct;63:100947. doi: 10.1016/j.yfrne.2021.100947. Epub 2021 Sep 27.
In endocrine/neuroendocrine tissues, excitability of secretory cells is patterned by the repertoire of ion channels and there is clear evidence that extracellular sodium (Na) ions contribute to hormone secretion. While voltage-gated channels involved in action potential generation are well-described, the background 'leak' channels operating near the resting membrane potential are much less known, and in particular the channels supporting a background entry of Na ions. These background Na currents (called here 'I') have the ability to modulate the resting membrane potential and subsequently affect action potential firing. Here we compile and analyze the data collected from three endocrine/neuroendocrine tissues: the anterior pituitary gland, the adrenal medulla and the endocrine pancreas. We also model how I can be functionally involved in cellular excitability. Finally, towards deciphering the physiological role of I in endocrine/neuroendocrine cells, its implication in hormone release is also discussed.
在内分泌/神经内分泌组织中，分泌细胞的兴奋性由离子通道的种类决定，并且有明确证据表明细胞外钠离子（Na）有助于激素分泌。虽然参与动作电位产生的电压门控通道已得到充分描述，但在静息膜电位附近起作用的背景“泄漏”通道却鲜为人知，尤其是支持钠离子背景内流的通道。这些背景钠电流（此处称为“I”）能够调节静息膜电位，进而影响动作电位发放。在这里，我们汇总并分析了从三种内分泌/神经内分泌组织收集的数据：垂体前叶、肾上腺髓质和内分泌胰腺。我们还模拟了I如何在功能上参与细胞兴奋性。最后，为了解I在内分泌/神经内分泌细胞中的生理作用，还讨论了其在激素释放中的意义。
