Solov'ev Iu N, Fedorova E N, Litvinova L V
Vopr Onkol. 1986;32(5):21-9.
The study was concerned with the analysis of peculiarities of pathomorphism development in osteogenic sarcoma under different therapeutic modalities. Material was obtained from 229 cases of tumor treated within 1955-1981. Electron microscopic examination of tumor was performed in 20 patients who had had no preoperative treatment and in 3 patients who had received adriamycin intraarterially and distant 60Co teletherapy (total focal dose 36 Gy) prior to surgery. Chondroid zones revealed posttreatment changes similar to spontaneous ones. Degenerative changes displayed by cells of osteo- and fibroplastic zones differed from spontaneous ones. They manifested themselves in the development of "posttreatment forms" with signs of lipophanerosis and hyperpermeability of nuclear and cytoplasmic membranes resulting in cell edema. Rupture of membrane pointed to an irreversible character of cell damage.
该研究关注不同治疗方式下骨肉瘤病理形态发展特点的分析。材料取自1955年至1981年间接受治疗的229例肿瘤病例。对20例未接受术前治疗的患者以及3例术前接受动脉内阿霉素注射和远距离60钴放射治疗（总局部剂量36 Gy）的患者的肿瘤进行了电子显微镜检查。软骨样区域显示出与自发变化相似的治疗后改变。骨样和成纤维样区域细胞所表现出的退行性变化与自发变化不同。它们表现为出现“治疗后形式”，伴有脂质显现以及核膜和细胞质膜通透性增加的迹象，进而导致细胞水肿。膜的破裂表明细胞损伤具有不可逆性。
