Fedorova E N
Arkh Patol. 1981;43(5):51-6.
Adriamycin was administered intraarterially and the tumor was irradiated at a total focal dose of 3600 rad in the preoperational period in 25 children suffering from osteogenic sarcoma. Histological examinations of the tumors revealed marked necrobiotic, necrotic and sclerotic changes. Within 2 months after the beginning of the therapy the number of tumor cells decreased, they were localized predominantly in the peripheral parts of the extraosseal component. Later in the same areas new generations of tumor cells were found. In 3 cases tumor cells were completely absent. The results suggest the efficacy of adriamycin in combination with radiation therapy in treatment of osteogenic sarcoma.
对25例骨肉瘤患儿在术前经动脉给予阿霉素，并对肿瘤进行照射，总焦点剂量为3600拉德。肿瘤的组织学检查显示有明显的坏死、坏死和硬化改变。治疗开始后2个月内，肿瘤细胞数量减少，主要局限于骨外成分的周边部分。后来在同一区域发现了新一代的肿瘤细胞。3例病例中完全没有肿瘤细胞。结果表明阿霉素联合放射治疗对骨肉瘤治疗有效。
