Ganzinger U, Stutz A, Petranyi G, Stephen A
Acta Derm Venereol Suppl (Stockh). 1986;121:155-60.
A new class of synthetic antifungal agents, characterized by an allylamine function as the essential structural feature, is reviewed. Two members of this class, identified by the generic name Naftifine and the code number SF 86-327 respectively, which were selected for further development from among several hundred analogous, are described in greater detail. As a class, the allylamines are highly active against dermatophytes and moulds, and moderately active against yeasts. Naftifine has been developed as an agent for the topical treatment of dermatomycoses, while SF 86-327 is under development in both topical and oral formulations, being the first orally applicable antifungal agent with a primarily fungicidal mode of action.
本文综述了一类新型的合成抗真菌药物，其主要结构特征为烯丙胺官能团。从数百种类似物中挑选出进一步研发的该类药物中的两个成员，分别为通用名萘替芬和编号SF 86 - 327，对其进行了更详细的描述。作为一类药物，烯丙胺对皮肤癣菌和霉菌具有高度活性，对酵母菌具有中等活性。萘替芬已被开发为局部治疗皮肤真菌病的药物，而SF 86 - 327正在进行局部和口服制剂的研发，它是首个主要具有杀菌作用方式的口服抗真菌药物。
