形态组学可预测细胞减灭性肾切除术治疗转移性肾细胞癌的肿瘤学特征和生存情况。
Morphomics Can Predict Oncological Features and Survival of Metastatic Renal Cell Carcinoma After Cytoreductive Nephrectomy.
机构信息
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C.
Cancer Genome Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C.
出版信息
Anticancer Res. 2021 Oct;41(10):5203-5211. doi: 10.21873/anticanres.15339.
BACKGROUND/AIM: This study analyzed the ability of body composition to predict the outcome of patients with metastatic renal cell carcinoma (RCC) who received cytoreductive nephrectomy followed by systemic therapy.
PATIENTS AND METHODS
A retrospective study was conducted from December 2010 to November 2017 in a single tertiary medical center. The medical charts and computed tomography images were reviewed. Statistical analysis included oncological features, their correlation with body composition factors, and overall survival.
RESULTS
Skeletal muscle volume was significantly higher in patients with Fuhrman grade 2 RCC than those with grade≥3. Patients with intermediate International Metastatic RCC Database Consortium risk had significantly higher BMI and skeletal muscle compared to those with poor risk. Multivariate analysis showed that increased skeletal muscle and decreased visceral adipose tissue were significant predictors of a better overall survival.
CONCLUSION
Body composition highly correlated with the oncological features of metastatic RCC and impacted survival.
背景/目的：本研究分析了体成分预测接受细胞减灭性肾切除术联合全身治疗的转移性肾细胞癌（RCC）患者预后的能力。
患者和方法
本回顾性研究于 2010 年 12 月至 2017 年 11 月在一家单中心三级医疗中心进行。对病历和 CT 图像进行了回顾。统计分析包括肿瘤特征、它们与体成分因素的相关性以及总生存期。
结果
RCC 患者的骨骼肌体积在 Fuhrman 分级 2 者中显著高于分级≥3 者。国际转移性 RCC 数据库联盟（IMDC）中危患者的 BMI 和骨骼肌明显高于低危患者。多变量分析表明，骨骼肌增加和内脏脂肪组织减少是总生存期更好的显著预测因素。
结论
体成分与转移性 RCC 的肿瘤特征高度相关，并影响生存。
Zotero 插件