Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Division of Medical Oncology, University of Washington, Seattle, WA, United States.
Front Immunol. 2021 Sep 14;12:715893. doi: 10.3389/fimmu.2021.715893. eCollection 2021.
Allogeneic stem cell transplantation (alloSCT) is a curative therapy for hematopoietic malignancies. The therapeutic effect relies on donor T cells and NK cells to recognize and eliminate malignant cells, known as the graft-versus-leukemia (GVL) effect. However, off target immune pathology, known as graft-versus-host disease (GVHD) remains a major complication of alloSCT that limits the broad application of this therapy. The presentation of recipient-origin alloantigen to donor T cells is the primary process initiating GVHD and GVL. Therefore, the understanding of spatial and temporal characteristics of alloantigen presentation is pivotal to attempts to separate beneficial GVL effects from detrimental GVHD. In this review, we discuss mouse models and the tools therein, that permit the quantification of alloantigen presentation after alloSCT.
异基因造血干细胞移植(alloSCT)是治疗血液系统恶性肿瘤的一种有治愈可能的疗法。这种疗法的疗效依赖于供者 T 细胞和 NK 细胞识别并清除恶性细胞,这种作用被称为移植物抗白血病(GVL)效应。然而,靶向外的免疫病理学反应,即移植物抗宿主病(GVHD),仍然是 alloSCT 的一个主要并发症,限制了这种治疗的广泛应用。供者 T 细胞识别受者来源同种异体抗原是引发 GVHD 和 GVL 的主要过程。因此,了解同种异体抗原呈递的时空特征对于试图将有益的 GVL 效应与有害的 GVHD 区分开来至关重要。在这篇综述中,我们讨论了允许在 alloSCT 后定量分析同种异体抗原呈递的小鼠模型和其中的工具。