School of Medicine and Medical Science, University College Dublin, Ireland.
University of Toronto, Ontario; Canadian Rheumatology Association Research Studentship, University of Western Ontario, Canada.
Clin Exp Rheumatol. 2021 Sep-Oct;39 Suppl 132(5):94-101. doi: 10.55563/clinexprheumatol/pt60bc. Epub 2021 Sep 17.
Children and adults may develop Behçet's disease (BD), often with ocular involvement such as uveitis. This study aimed to determine the prevalence and type of ocular manifestations in childhood and adult BD.
Medline, Web of Science and Cochrane databases were searched from inception to October 5, 2018 to identify publications related to Behçet's disease comprising minimum twenty patients and providing the frequency of ocular manifestations (OC). Random effects models were used to combine the prevalence of OC in adults and children with BD. Heterogeneity was evaluated using I2.
The search resulted in 3129 articles, of which 51 were included in meta-analysis. OCs were slightly more frequent in childhood onset BD with the mean [95% Confidence Interval] frequency of 45 [34-56%] compared to 36 [29-43%] in adults, however, this difference was not statistically significant (p=0.198). In both children and adults, posterior uveitis (children 27% vs. adults 25%, and retinal vasculitis in adults 16%) was the most common ocular manifestation, followed by anterior uveitis (children 18% vs. adults 23%). When comparing the distribution of OC in Behcet's in adults, there was geographic variation where OC were higher in Turkey and the Middle East 42%, followed by Europe and North America (36%), North Africa 26% and East Asia 25% but not significantly (p=0.27).
Ocular manifestations, predominantly uveitis; are common in BD. Ocular manifestations are not proportionately more frequent in adults with BD along the ancient Silk Road.
儿童和成人都可能患贝赫切特病（BD），常伴有葡萄膜炎等眼部受累。本研究旨在确定儿童和成人 BD 的眼部表现的患病率和类型。
从建库至 2018 年 10 月 5 日，检索 Medline、Web of Science 和 Cochrane 数据库，以确定与包含至少 20 例患者且提供眼部表现（OC）频率的贝赫切特病相关的出版物。使用随机效应模型对成人和儿童 BD 的 OC 患病率进行合并。采用 I2 评估异质性。
搜索结果产生了 3129 篇文章，其中 51 篇文章纳入了荟萃分析。儿童发病 BD 的 OC 略为常见，平均（95%置信区间）频率为 45%[34-56%]，而成人则为 36%[29-43%]，但差异无统计学意义（p=0.198）。在儿童和成人中，后葡萄膜炎（儿童 27% vs. 成人 25%）和视网膜血管炎（成人 16%）是最常见的眼部表现，其次是前葡萄膜炎（儿童 18% vs. 成人 23%）。在比较成人贝赫切特病 OC 的分布时，存在地域差异，OC 在土耳其和中东地区的发生率较高，为 42%，其次是欧洲和北美地区（36%）、北非地区（26%）和东亚地区（25%），但差异无统计学意义（p=0.27）。
眼部表现，主要是葡萄膜炎，在 BD 中很常见。在古代丝绸之路上，BD 成人中眼部表现并不成比例地更为常见。
